VanA-Positive Vancomycin–Resistant Staphylococcus aureus: Systematic Search and Review of Reported Cases


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Abstract

At the 10th anniversary of the first report of vanA vancomycin-resistant Staphylococcus aureus (VRSA), we aimed to determine the total number of vanA-VRSA reported in the literature. Relevant key words were used to search through PubMed, Sciverse, and Google Scholar, as well as the abstract book of recent related meetings, university theses, and the CDC website. All studies reporting vanA-positive S aureus confirmed by the polymerase chain reaction were included. Final analysis revealed that 33 VRSA isolates have been reported worldwide, of which one isolate was from Pakistan, 3 isolates were from Iran, 13 isolates were from the United States, and 16 isolates were from India. One Indian isolate was susceptible to methicillin. Possible community origin and nasal carriage of VRSA cases have been recently described in the literature. This study showed that vanA-VRSA seems to be still limited, but more than half of the reported VRSA cases were not included in previous reviews.

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