Angiogenesis imaging in myocardial infarction using : characterization and application to therapeutic efficacy monitoring in rats68: characterization and application to therapeutic efficacy monitoring in ratsGa-NOTA-RGD PET: characterization and application to therapeutic efficacy monitoring in rats

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Abstract

Objective

68Ga-NOTA-RGD PET is a newly developed molecular imaging for angiogenesis. In this study, 68Ga-NOTA-RGD PET was used to investigate imaging characteristics in a rat myocardial infarction (MI) model and to monitor the efficacy of an angiogenesis induction therapy.

Materials and methods

68Ga-NOTA-RGD PET was performed serially in rats with MI or sham operation, and myocardial uptake was analyzed with respect to time duration and tissue characteristics. Subsequently, 68Ga-NOTA-RGD PET was serially performed for therapeutic efficacy monitoring in MI-induced rats, which were treated with basic fibroblast growth factor (bFGF) injection or saline injection. Image findings were compared with the final change in MI lesion.

Results

68Ga-NOTA-RGD uptake was significantly increased in MI lesion and gradually decreased over time. 68Ga-NOTA-RGD uptake in the infarcted tissue corresponded with vascular endothelial growth factor expression and macrophage accumulation. In monitoring of therapeutic efficacy, the lesion uptake in the bFGF-injected group was significantly higher than that of the saline-injected and sham-operated groups on the first day. However, no significant differences were observed between bFGF and saline-injected groups at subsequent time points, corresponding to the final infarct size change.

Conclusion

68Ga-NOTA-RGD PET would be a useful angiogenesis imaging modality in MI for assessment of pathophysiology or monitoring of therapeutic efficacy.

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