*Inotek Pharmaceuticals Corporation, Beverly, MA 01915; †Department of Surgery, New Jersey Medical School, UMDNJ, Newark, NJ 01703; ‡Critical Care Division, Department of Internal Medicine, University Hospital, Lausanne, Switzerland; §Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary; ∥Department of Anesthesiology, Faculty of Medicine, University of Tromso, Tromso, Norway; and ¶Northern State Medical University, Arkhangelsk, Russia