Thrombin Role In Inflammatory Signaling

S. Jelacic; G. O'keefe

Issn Print: 1073-2322

Publication Date: 2006/06/01

THROMBIN ROLE IN INFLAMMATORY SIGNALING

S. Jelacic; G. O'Keefe


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Excerpt

Sepsis is associated with a systemic activation of coagulation and an excessive inflammatory response. Thrombin has been shown to have an effect on leukocyte activation. This indicates that thrombin may play a role in the onset of inflammation by recruiting and activating inflammatory cells. Our studies were aimed at determining intracellular responses of monocytes to thrombin in comparison to endotoxin.


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