Issn Print: 1073-2322
Publication Date: 2006/06/01
THE PI-3K SIGNALING PATHWAY HAS AN OVERALL PROTECTIVE ROLE FOR NEUTROPHIL ACTIVATION AND SURVIVAL IN SEPSIS
N. Tabriz; T. Barkhausen; M. Van Griensven; C. Krettek; N. Riedemann
Excerpt
Activation of the Pi-3K/AKT pathway via C5a results in inhibition of neutrophil apoptosis. Recent work suggests that this pathway may be involved in controlling mediator generation during acute inflammation. We thought to investigate the effects of C5a on Pi3-kinase/AKT-pathway activation in human neutrophils and its effects on proinflammatory mediator generation during sepsis in rodents.
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