Analysis Of Stat3 Transcriptional Activity And Socs3 Mrna Expression In Pmn Of Multiple Trauma Patients In The Early Posttraumatic Period

J. Stegmaier; C. Kirchhoff; H. Vester; V. Bogner; K.g. Kanz; W. Mutschler; P. Biberthaler

Issn Print: 1073-2322

Publication Date: 2006/10/01

ANALYSIS OF STAT3 TRANSCRIPTIONAL ACTIVITY AND SOCS3 MRNA EXPRESSION IN PMN OF MULTIPLE TRAUMA PATIENTS IN THE EARLY POSTTRAUMATIC PERIOD

J. Stegmaier; C. Kirchhoff; H. Vester; V. Bogner; K.G. Kanz; W. Mutschler; P. Biberthaler


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Excerpt

Destabilisation of the human immune system following severe trauma induces Systemic Inflammatory Response Syndrome, SIRS and Multiple Organ Failure, MOF. In this context, Suppressors of Cytokine Signaling, (SOCS) seem to play a substantial role for modulation of cytokine expression after trauma, which are controlled by Signal Transducers and Activators of Transcription, STAT3. Although it was demonstrated in animal models that i.e. SOCS3 mediates part of the posttraumatic immune modulation its role within human PMN obtained from multiple injured patients remains unclear, so far.


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