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Comparison of the biomechanical fixation strengths offered by 3 iliac screw fixation techniques: short screw, short screw augmented with cement, and long screw.Evaluate the effect of screw length and bone cement augmentation on the fixation strength of iliac screw upon fatigue loading.Iliac screws have been used in treating spinal disorders such as spinal deformity, spondylolisthesis, and sacral tumor. In clinical practices, both short screws and long screws are being used. It has been reported that short iliac screws have a higher rate of loosening. Therefore, short iliac screws are being used with bone cement augmentation to improve fixation. To date, no biomechanical study has compared the strengths of these 3 different iliac screw fixation techniques.Fresh, frozen human cadaveric pelvis specimens (n=18, 12 males, 6 females, average age 61 y) were used. Bone density was measured to characterize bone quality. The specimens were randomly divided into 2 groups. In group 1 (n=8), short screws of 7.0-mm diameter and 70±4 mm length (as the length of exceeding over ischial notch) and long screw of 7.0-mm diameter and 120±4 mm length were placed on either side of the pelvis (left and right). In group 2 (n=10), short iliac screws were placed after augmentation with polymethyl methacrylate bone cement on 1 side of the pelvis and long iliac screw were placed on the other side (left and right). Cyclic loading ranging from 20 to 200 N was applied to each screw at a frequency of 2 Hz up to 5000 cycles. Pullout tests were then conducted at the rate of 5 mm/min after the fatigue test, and the maximum pullout strength for each screw was recorded and analyzed.The maximum pullout strength of the long screw and short screw groups after fatigue conditioning were 2386±1470 and 833±681 N respectively. Significant difference was found between the 2 groups (P<0.05). The short iliac screw had a higher loosening rate. The pullout force of the short screw fixation with augmentation and the long screw fixation after cyclic loading were 2436±915 and 2529±1055 N, respectively. No significant difference was found between the 2 groups (P>0.05).Short iliac screws are susceptible to loosening after cyclic loading. Bone cement augmentation of short screws has demonstrated a significant increase in the fixation strength of short screws to an extent similar to that of long iliac screws. Thus, short iliac screw fixation after augmentation with bone cement will be a viable clinical option for spino-pelvic reconstruction.