Psychiatric Genetics. 20(4):171-178, AUGUST 2010

DOI: 10.1097/YPG.0b013e32833a20b9

,  

PMID: 20421848

Issn Print: 0955-8829

Publication Date: August 2010


Share this on facebook   Share this on Twitter   Share this on LinkedIn   Email this article  



Print

Interactions between functional serotonergic polymorphisms and demographic factors influence personality traits in healthy Spanish Caucasians

Pilar Saiz;Maria Garcia-Portilla;Rocío Herrero;Celso Arango;Paul Corcoran;Blanca Morales;Maria-Teresa Bascarán;Victoria Alvarez;Eliecer Coto;Begoña Paredes;Juan Fernández;Julio Bobes;

+ Author Information


    loading  Checking for direct PDF access through Ovid

Abstract

BackgroundData from epidemiological genetic studies suggest that variability in personality traits is explained, at least partly, by genetic factors. Recently, a growing number of molecular genetic studies have suggested the involvement of the serotonin system in specific traits.ObjectiveTo investigate the association between three serotonergic polymorphisms [A-1438G (rs6311) of the HTR2A gene, and STin2 VNTR and 5-HTTLPR of the SLC6A4 gene] and personality traits assessed with the Temperament and Character Inventory.Materials and methodsFour hundred and four unrelated healthy volunteers [50% males, mean age (standard deviation)=40.5 (11.3)] from Asturias (northern Spain) were genotyped using standard methods. Cloninger's Temperament and Character Inventory was used for investigation of temperament and character traits.ResultsThe genetic variants were in Hardy–Weinberg equilibrium and genotypic frequencies were similar in both the sexes. 5-HTTLPR was associated with a direct effect on self directedness (F=6.20, P=0.002), and interacting with educational level (F=3.10, P=0.016) and A-1438G (F=3.34, P=0.011) with respect to novelty seeking. STin2 VNTR interacted with age in relation to reward dependence (F=2.74, P=0.013) and with sex in relation to cooperation (F=5.10, P=0.007). In addition, SLC6A4 haplotypes had significant effects on harm avoidance (lower in volunteers with L12), self directedness (higher in volunteers with L12), and self transcendence (higher in volunteers with S10).ConclusionOur findings suggest a strong genetic component in personality traits manifested primarily through interaction effects that occur between genetic factors alone and between genetic and demographic factors.

Related Topics

    Related Articles

        loading  Loading Related Articles