Drug interactions in transplant patients: what everyone should know


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Abstract

Purpose of reviewAdverse events due to drug–drug interactions remain a challenge in the postsurgical care of transplant recipients. A combination of potent and selective immunosuppressive drugs, which have a narrow therapeutic index, with medications for the treatment of comorbidities such as dyslipidemia, infection, psychiatric conditions, and hypertension, can lead to life-threatening drug–drug interactions.Recent findingsThere are a number of important drug–drug interactions which are important for physicians to consider. It is critical to understand the pharmacodynamics and pharmacokinetics of drug–drug interactions, their potential impact on patient care, and the management strategies.SummaryClose therapeutic drug monitoring and evaluation of drug-specific side effects continue to be an important key to minimize adverse events due to drug–drug interactions.

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