Issn Print: 1072-3714

Publication Date: 1999/01/01


Print

Noninvasive Assessment of Oral Estrogen Replacement on Endothelial Function in African American and Caucasian Postmenopausal Women: P-96.

P Brovne; B Soltes; S Hollenberg; A Dumasius

+ Author Information

Author Information: Reproductive Endocrinology and

    loading  Checking for direct PDF access through Ovid

Excerpt

Objective: The aim of the stud>y was to evaluate racial differences in endothelial function and changes in lipid profile in postmenopausal (PMP) women after estrogen replacement therapy (ERT).
Design: Prospective study of 17 PMP women of which 10 were African American (AA) and 7 were Caucasian. Pre and post measurement brachial artery ultrasounds and lipid profiles were performed after 12 weeks of ERT. Brachial artery ultrasounds included measurements of nitric oxide (NO) dependent and independent vasodilatation.
Results: There were no significant differences in BMI. blood pressure, and waist hip ratio between the two groups. AA had a greater improvement in lipid profiles after ERT compared with Caucasians. The collective study population showed significant improvement in NO-dependent vasodilatation after ERT (p = 0.046); however there was a slightly greater improvement in the Caucasian group compared with the AA group. There was no significant change in NO-independent vasodilatation in either or between the groups after ERT.
Conclusions: ERT improves endothelial function in both AA and Caucasian women. Caucasians have a slightly greater improvement in endothelial function, whereas AA have greater improvement in lipid profiles after ERT. Racial differences in the cardiovascular benefit of ERT may be present, but larger cohort will be needed to elucidate these differences.

Related Topics

    loading  Loading Related Articles