Injectable Poly-l-Lactic Acid: 3 Years of Aesthetic Experience

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Abstract

BACKGROUND

Injectable poly-l-lactic acid (PLLA) has been used to correct age- or disease-related facial volume deficits.

OBJECTIVE

This single-center, retrospective survey evaluated PLLA for cosmetic use.

METHODS AND MATERIALS

A questionnaire was mailed to 281 patients treated with PLLA 6 months or more previously. PLLA was reconstituted 4 hours or more before injection with 5 mL of sterile water plus 1 mL of 1% xylocaine added before injection.

RESULTS

Two hundred twenty-one patients responded (210 female; average age 54.3; average treatments 3.3 per patient); the majority had received facial injections. Transient side effects included bruising, swelling, and discomfort. After treatment (1–6 months), 14/41 patients developed Grade 1 papules or nodules (slightly palpable, nonvisible; clinically nonrelevant; all resolved spontaneously), 15/41 developed Grade 2 papules or nodules (palpable, slightly visible; clinically nonrelevant; all resolved spontaneously), and 12/41 developed Grade 3 nodules (easily palpable, obviously visible [9 perioral; 3 periorbital or temple]; 5 resolved spontaneously; 7 were treated [5 intralesional corticosteroids; 2 surgery]).

CONCLUSION

Patients treated with PLLA experienced duration of improvement of up to 24 months. Maximum improvement took several treatment sessions. Nodules occurred in perioral and periorbital regions, so incidence is reduced by avoiding these areas.

CONCLUSION

Dermik Laboratories, a business of sanofi-aventis UK, and the Cranley Clinic provided financial support for this independent study.

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