Gastric α-tocopherol and β-carotene concentrations in association withHelicobacter pyloriinfection

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Abstract

Objective

The effects ofHelicobacter pyloriinfection and its associated gastric histology on α-tocopherol and β-carotene concentrations in serum, gastric juice and antral mucosa were investigated in patients undergoing routine gastroscopy for investigation of dyspepsia.

Method

Eighty-six patients were studied. Highperformance liquid chromatography was used to measure α-tocopherol and β-carotene concentrations.H. pyloriinfection was assessed by histology, bacterial culture, rapid urease test and serology.

Results

No obvious association was found between age, sex, smoking or endoscopic diagnosis and α-tocopherol or β-carotene concentrations in serum, gastric juice and antral mucosa. However, alcohol drinkers had significantly lower antral mucosal and gastric juice β-carotene concentrations compared to non-drinkers. Gastric juice β-carotene concentration was markedly lower in patients infected withH. pylorithan uninfected controls (2.9 nmol/l (interquartile range 0.3-4.3) versus 4.6 nmol/l (interquartile range 3.5-7.6),P= 0.01), but there was no significant difference in serum or gastric mucosal β-carotene concentrations between the two patient groups. The presence of gastric atrophy and intestinal metaplasia was significantly associated with reduced mucosal α-tocopherol and β-carotene concentrations. Furthermore, antral mucosal α-tocopherol concentrations decreased progressively as antral mucosal histology changed from normal to chronic gastritis alone and finally to atrophy and intestinal metaplasia.

Conclusion

Gastric α-tocopherol and β-carotene concentrations are affected byH. pylori-associated gastric histological changes, and these findings suggest thatH. pyloriinfection may not only impair the protective role of vitamin C, but also of α-tocopherol and β-carotene in the stomach.Eur J Gastroenterol Hepatol12:497-503

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