DOI: 10.1097/MEG.0b013e3283417f76

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PMID: 21191307

Issn Print: 0954-691X

Publication Date: 2011/03/01


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Heme oxygenase-1 polymorphism is not associated with riskof colorectal cancer: a Danish prospective study

Vibeke Andersen; Jane Christensen; Kim Overvad; Anne Tjønneland; Ulla Vogel

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Author Information: Medical Department, Viborg Regional Hospital, Viborg

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Abstract

Objective

Intake of red and processed meat confers risk of colorectal cancer (CRC). We wanted to test whether heme in meat promotes carcinogenesis.

Methods

Heme oxygenase-1 (HO-1, HMOX1) A-413T (rs2071746) was assessed in a nested case–cohort study of 383 CRC cases and 763 randomly selected participants from a prospective study of 57 053 individuals. Incidence rate ratios and 95% confidence intervals were calculated.

Results

No association was found between the HO-1 polymorphism and CRC (P value for trend for the fully adjusted estimates=0.29). No interaction with meat intake was found (P value for interaction=0.55).

Conclusion

The studied HO-1 polymorphism was not associated with risk of CRC suggesting that heme from meat is not important in CRC development.

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