Adequate bowel preparation is an important step for an effective colonoscopy. Polyethylene glycol solution (Kleanprep) and sodium picosulphate with a magnesium citrate solution (Picoprep) are bowel cleansing agents registered and available for this purpose. So far, the results of studies comparing the effectiveness of bowel cleansing between the two agents are inconclusive. This may be because of differences in administration regimes and subjective measurement of bowel cleansing.Objectives
In this single-blinded randomized-controlled trial, the effectiveness of Kleanprep and Picoprep was examined using a split-dose regimen and an objective bowel cleansing score system.Patients and methods
One hundred and seventy-three consecutive patients referred for outpatient colonoscopy were included, the required number based on power analysis. Eighty-eight patients received Kleanprep; 85 received Picoprep. The primary outcome was the effectiveness of bowel cleansing using the Boston Bowel Preparation Score. The secondary outcome was patient tolerability measured using a questionnaire. An intention-to-treat-analysis was carried out.Results
The overall Boston Bowel Preparation Score between Kleanprep and Picoprep was not significantly different (P=0.182). On reviewing segment scores, there were also no significant differences between Kleanprep and Picoprep. Patients using Picoprep scored significantly better on the aspects of convenience and flavour of the preparation agent compared with patients using Kleanprep (P<0.001). Side effects such as nausea (P=0.011), vomiting (P=0.001), headache (P=0.003) and bloating (P<0.001) were experienced less significantly by patients using Picoprep.Conclusion
The present study did not find a difference in the effectiveness of bowel cleansing between Kleanprep and Picoprep. Both were found to be adequate cleansing agents. Picoprep was significantly better tolerated than Kleanprep. Therefore, we recommend Picoprep as a first-choice regimen for bowel preparation before colonoscopy.