Nongestational Choriocarcinoma in the Postpartum Period: A Case Report

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Purpose: To determine the tissue of origin (gestational versus nongestalional) of an extensive metastatic choriocarcinoma in an 18-year-old woman to determine prognosis and treatment.Methods: DNA microsatellite polymorphisms after polymerase chain reaction (PCR) amplification of the tumor tissue and blood from the patient, husband, and daughter were used to determine the tissue of origin.Results: Molecular analyses revealed that the tumor shared the genetic features of only the patient. She responded well to multiagent chemotherapy.Conclusions: Molecular analysis is a useful tool to determine whether a choriocarcinoma occurring in a female patient of child-bearing age is gestational or nongestational when clinical findings are not clearly indicative of the primary.

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