Prostaglandin Inhibitors in the Treatment of Single-system Langerhans Cell Histiocytosis: Pharmacologic Rationale and Report of Two Cases

    loading  Checking for direct PDF access through Ovid


Therapeutic trials have confirmed the efficacy of a number of approaches to the treatment of single-system Langerhans cell histiocytosis (LCH). Not so well studied, but with some pharmacologic rationale and anecdotal reports of clinical success, are prostaglandin inhibitors. We present here a review of the possible mechanism of action of prostaglandin inhibitors in LCH and 2 cases of single-organ, single-site LCH treated with only prostaglandin inhibitors, both with sustained favorable clinical outcomes.

    loading  Loading Related Articles