DOI: 10.1097/MPH.0b013e3181ed3384

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PMID: 21127433

Issn Print: 1077-4114

Publication Date: 2011/03/01


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The Role of Standard-dose Cytarabine in Children With Acute Promyelocytic Leukemia: A Single-center Experience

Li Zhang; Xiaofan Zhu; Xiaojuan Chen; Yumei Chen; Yao Zou

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Abstract

Background

There are very limited data reported about the role of cytarabine (Ara-C) in childhood acute promyelocytic leukemia (APL). We review the clinical course and treatment outcome of APL and explore the role of standard-dose Ara-C for children.

Procedure

Between January 1999 and December 2008, 36 children (<14 y) with newly diagnosed APL were included.

Results

The overall complete remission rate was 97.2% (35/36). Two patients were lost to follow-up after induction. Two groups of patients were identified according to different consolidation chemotherapy regimens. Seventeen patients were given polychemotherapy in combination with standard-dose Ara-C (group I), 16 patients were given daunorubicin alone (group II). Although the 5-year estimate of disease-free survival between groups I and II had no statistically significant difference (P=0.614), there was a 12% higher disease-free survival rate for group I.

Conclusion

Standard-dose Ara-C might play some role in the consolidation treatment of children suffering from APL.

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