Progress in the understanding of the vascular etiology of glaucoma

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Cumulative evidence strongly indicates that glaucomatous optic neuropathy is a multifactorial disease with many systemic and ocular factors acting in different combinations to interfere with optic nerve head circulation—the final common pathway in the production of glaucomatous optic neuropathy. The vital prerequisite for an understanding of the vascular etiology of glaucomatous optic neuropathy is an adequate basic knowledge of the factors that control optic nerve head blood flow. This review summarizes current knowledge of that, and discusses briefly many conditions and factors that can influence the optic nerve head blood flow and development of glaucomatous optic neuropathy along with recent advances made in those areas.

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