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To investigate if specific classes of antiglaucoma medications have an influence on selective laser trabeculoplasty (SLT) success.This retrospective prediction rule analysis investigated 120 eyes from 120 patients diagnosed with either open angle glaucoma or ocular hypertension, who underwent SLT treatment. Treatment success was defined as ≥20% intraocular pressure (IOP) reduction at 3 and 6 months after the treatment date. Multivariate logistic regression analyses were performed to determine success predictors.Pre-SLT IOP (up to 4 wk before SLT therapy) was the only independent predictor for ≥20% IOP reduction with an odds ratio of 1.30 when controlling for pre-SLT antiglaucoma drops. The area under receiver operator characteristic curve was 0.777.Topical medications do not adversely, nor favorably, affect SLT success. SLT efficacy is positively associated with the degree of IOP elevation before SLT treatment. Pigmentation of the anterior chamber angle, class of antiglaucoma medications, diabetes, sex, corneal thickness, pseudophakia, diagnosis, washout of eye drops, and previous argon laser trabeculoplasty treatment are not associated with SLT treatment efficacy.