To determine the potential of anterior-segment optical coherence tomography (AS-OCT) to predict post-trabeculectomy outcomes in NVG.Patients and Methods:
We recruited fifty-five eyes of 40 NVG patients who underwent trabeculectomy. The patients were divided into success and failure groups based on the post-trabeculectomy outcome after 12 months. AS-OCT findings were compared in the success and failure groups at 1 and 2 weeks and 1, 3, 6, and 12 months. We also analyzed early post-trabeculectomy bleb parameters with multiple logistic regression, stepwise multiple regression, and the receiver operator curve (ROC) to evaluate the power of these parameters to predict long-term outcomes.Results:
IOP at 6 and 12 months was lower in the success group than the failure group (P < 0.0016,=0.0048). Reflectivity of the bleb wall was higher in the failure group than the success group throughout the study (all: P<0.0016). Age and reflectivity of the bleb wall at 1 week were risk factors for failure with odds ratios for failure of 0.91 and 1.67. The AUC for reflectivity of the bleb wall at 1 week was 0.943 with the cutoff set at 128.9 (sensitivity: 85.7%, specificity 100.0%). Stepwise multiple regression analysis showed that reflectivity of the bleb wall at 1 week independently indicated the bleb survival period (β=−0.84, P<0.001).Conclusions:
AS-OCT-measured reflectivity of the bleb wall, measured at 1 week of trabeculectomy for NVG, might be able to predict of the final status of the bleb.