Issn Print: 0969-9546
Publication Date: 2001/03/01
Acute respiratory distress and multiorgan failure after ingestion of glufosinate
Excerpt
Acute respiratory distress and multiorgan failure after ingestion of glufosinate F. Grossenbacher1, M.O. Rambourg Schepens1, A.L. Dardenne2, A. Delvaux2 and R. Bertault11Toxicovigilance-Réanimation-SAMU, CHU Reims;2SAU-SMUR CH Epernay, France Glufosinate is a widely used herbicide; commercial preparations contain glufosinate-ammonium (150 g/l), an anionic surfactant (sodium lauryl ether sulphate, 59%) and propylene glycol monomethylether (10%). Clinical features of acute glufosinate toxicity usually include early gastrointestinal disorders, followed by neurological manifestations (coma, convulsions) occurring within 10–36 hours post ingestion, associated with severe respiratory and haemodynamic disturbances. We report the case of a 51-year-old man who intentionally ingested several mouthfuls of the concentrated herbicide; this was associated with severe corrosion of the oesophagus (grade III), acute renal failure, hepatitis and jaundice, and acute respiratory distress syndrome; death occurred 5 days after ingestion from multiorgan failure and cardiogenic shock.
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