Balancing the risk and rewards of utilizing organs from hepatitis C viremic donors


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Abstract

Purpose of reviewOwing to long waitlist times and high waitlist morbidity and mortality, strategies to increase utilization of hepatitis C viremic-deceased donor organs are under investigation in kidney, liver, heart, and lung transplantation.Recent findingsDirect-acting antiviral medications for hepatitis C virus infection have high cure rates and are well tolerated. Small, single-center trials in kidney and heart transplant recipients have demonstrated that with early posttransplant direct-acting antiviral therapy, 100% of uninfected recipients of hepatitis C viremic organs have been cured of infection after transplantation.SummaryIn this manuscript, we review the risks and rewards of utilizing hepatitis C viremic organs for transplantation.

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