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This study compared metabolic cost and cost:work ratio to blood pressure and heart rate response between circuit and traditional weight training. Subjects (5 M, 3 F) completed one traditional and one circuit weight training workout. O2 was measured during workout and recovery. Total work was calculated by summing the vertical work on the weights and limbs. Heart rate was continuously monitored. SBP and DBP were measured during the last 10 set of each leg exercise and once a minute during recovery. Cost:work ratios were significantly higher for traditional weight training (p = 0.003). However, due to the greater total workload, total metabolic cost was higher for circuit weight training (p = 0.032). Exercise and recovery rate-pressure product (RPP) were calculated. Exercise heart rate was significantly higher during circuit weight training. No differences were found in BP response. Exercising RPP was significantly higher during circuit weight training, indicating a higher workload on the heart. This may be an important consideration when recommending weight training programs for persons with cardiovascular complications.