The purpose of this series of investigations was to gain insight on resistance training in American football and address some of the myths. Many theories about resistance training have been proposed, yet there has been little if any research on some of these training philosophies. This series of studies represents an accumulation of data that helped to formulate a training approach. Rather than having a training philosophy, it might be more productive to have a training approach based on facts and critical monitoring of test variables representative of the physical development possible through strength and conditioning programs. It was demonstrated that football players are capable of multiple maximal efforts in resistance training and that the length of the rest period was a determining factor. In general, multiple sets and various periodized training programs were superior to single-set programs in the rate and magnitude of improvements in body composition, strength, local muscular endurance, and power. Such data indicate that for building programs in previously trained football players, multiple-set programs that provide variation are more appropriate.