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This study compared the physical and physiological alterations that occurred in male high school and college students as a result of a 6-week endurance training program. Fifty-one students, ages 15 to 21, were assigned to 1 of 3 groups: road (n = 14), sand (n = 19), or control group (n = 18). The 12-min run/walk test, vertical jump (VJ), and thigh and calf circumference were measured pre- and posttraining. One-way ANOVA, paired t-test, and Tukey test were used to evaluate the effects of training. Sand runners and road runners had a similar significant (p < 0.05) increase in thigh circumference. Calf circumference increased significantly in sand runners. Both treatment groups showed a similar significant increase in vertical jump. The 12-min run/walk was significantly increased in sand runners. This study shows that a 6-week sand running program may result in the most physiological and performance changes in young men.