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The aim of this study was investigate the effects of transcranial direct current stimulation (tDCS) on volume-load and ratings of perceived exertion. Fifteen young healthy individuals, aged between 20 and 30 years in advanced strength training were recruited. Test and retest of the 10 maximum repetitions (10RM) were performed to determine the reliability of load utilized. Subjects performed three experimental conditions in a randomized, double-blinded crossover design: anodic stimulation (a-tDCS), cathodic stimulation (c-tDCS) and sham (2 mA for 20 minutes targeting the dorsolateral prefrontal cortex cortex left). Immediately after the experimental conditions, subjects completed one set of maximum repetitions with 10RM load (volume-load) and answered to OMNI-RES (Post-stimulation) (level of significance p ≤ 0.05). The volume-load showed main effect for condition (F(2, 28)= 164.801; p<0.001). In post-stimulation, a-tDCS was greater than c-tDCS (p ≤ 0.001), and sham (p ≤ 0.001). For ratings of perceived exertion (OMNI-RES), the results showed main effect for condition (F(2, 28)=9.768; p ≤ 0.05). In post-stimulation, c-tDCS was greater than a-tDCS (p ≤ 0.05), and sham (p ≤ 0.05). We conclude that the use of a-tDCS may promote increased in volume-load for the LP45 exercise. Moreover, higher-volume loads are necessary to maximize muscle strength and anabolism.