The focus of the investigation was to examine the effects of citrulline malate on muscular fatigue in healthy, recreationally trained participants. Twelve participants (males = 6; females = 6) (24.1 ± 3.9 yrs) visited the lab on three separate days all separated by one week. Each visit consisted of consuming one of three treatments: placebo (PLA), citrulline malate (8 g) (CM), and control (CON) in which no drink mixture was consumed. For each day of testing, participants consumed assigned treatment and performed one high-intensity exercise trial consisting of squats, lunge jumps, squat jumps, and lateral jumps. Participants performed the exercises in the listed order, which was designated as one round. Each participant performed 3 rounds, with the work to rest ratio being 20 sec work, 30 sec rest. A one min rest was given between rounds. A pre/post-exercise isokinetic leg extension test was performed to measure for peak power, peak torque, and rate of fatigue. Additionally, blood lactate was obtained pre/post-exercise. There were no treatment or interaction effects (p > 0.05) for peak torque, peak power, rate of fatigue, or blood lactate accumulation. However, there was a statistical significant decrease from pre/post-ex for peak torque (p = 0.003), peak power (p = 0.003), and rate of fatigue (p = 0.001). Additionally, lactate accumulation did increase significantly from pre/post-ex (p = 0.0001). Lastly, neither total work nor final heart rate was statistical significant between the treatments (p > 0.05). Citrulline malate was not effective in improving performance or alleviating fatigue following a high-intensity exercise session.