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Nurses practicing in the rural setting have faced a unique challenge in maintaining competency in low-volume, high-risk procedures. This study assessed the effectiveness of a focused, multifaceted educational intervention on the retention of nursing knowledge related to central venous access devices care and maintenance. A pretest-posttest intervention study design was used at a 58-bed rural healthcare facility in a Western state. This study demonstrates a statistically significant increase in functional nursing knowledge in the postintervention period.