DOI: 10.1097/01.rhu.0000226557.50298.dd
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Issn Print: 1076-1608
Publication Date: 2006/08/01
TNFa-e MICROSATELLITE POLYMORPHISMS ARE ASSOCIATED WITH RHEUMATOID ARTHRITIS SUSCEPTIBILITY IN BRAZILIAN PATIENTS: 111
Excerpt
Association of the major histocompatibility complex (MHC) with genetic predisposition to rheumatoid arthritis (RA) has been extensively studied; however, in about 25% of patients MHC alleles are not associated to disease susceptibility. Six polymorphic TNF-a-f microsatellite alleles have been described, and some of them have been associated with susceptibility or protection to rheumatoid arthritis in many populations. The aim of this study was to evaluate TNFa-e microsatellite polymorphisms in 39 female Brazilian rheumatoid arthritis patients, diagnosed according to the criteria of the American College of Rheumatology, followed at the University Hospital of the Faculty of Medicine of Ribeirão Preto-USP, and in 101 healthy female individuals. TNFa-e microsatellite polymorphisms were analyzed using DNA amplified by the polymerase chain reaction and hybridized with sequence-specific primers. The two-tailed exact Fisher exact test was used for statistical analysis. Significance was achieved with a P value <0.05. TNFd1 and d3 microsatellite alleles conferred susceptibility to RA (P < 0.0001; RR = 4.36), whereas TNFa2 and d4 alleles conferred protection against RA development (P < 0.0001; RR = 3.52). In conclusion, TNFa-e microsatellite polymorphisms are associated to RA susceptibility in Brazilian RA patients. Furthers studies are necessary to confirm these observation in others populations in Brazil.
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