DOI: 10.1097/01.rhu.0000226770.07419.12
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Issn Print: 1076-1608
Publication Date: 2006/08/01
LYMPHOCYTE SUBPOPULATIONS IN SYSTEMIC LUPUS ERYTHEMATOSUS: 169
Excerpt
Different patterns of lymphocyte subpopulations have been described in systemic lupus erythematosus (SLE). Lymphocyte depletion is observed in patients with active SLE. The purpose of this study was to determine lymphocyte subset composition in SLE patients. Lymphocyte subset of twenty female patients, aged between 16–46 years (mean = 26.9 years), presenting with SLE according to the American College of Rheumatology criteria, and followed at the University Hospital of the Faculty of Medicine of the Federal University of Ceará, Brazil, and 20 healthy female individuals aged between 16–48 years (mean = 32.5 years), were determined by flow cytometry. Anti-CD3-FITC, anti-CD19-PE, anti-CD4-FITC, anti-CD8-PE and anti-CD56-PE were used to identify T, B, helper, cytotoxic and natural killer (NK) lymphocytes, respectively. All patients were under treatment with corticoids associated or not with chloroquin. Student T test was used for statistical analysis. We observed fewer CD3, CD4 and CD8 cells in SLE when compared with controls (1,259.3 cel/mm3 versus 2,033.7 cel/mm3, P < 0.05; 766.5 cel/mm3 versus 1,227.4 cel/mm3, P < 0.05 and 428.6 cel/mm3 versus 713.3 cel/mm3, P < 0.05, respectively). Additionally, a tendency to a decrease in number of CD19 and NK cells was observed (282.2 cel/mm3 versus 346.0 cel/mm3 and 63.9 cel/mm3 versus 154.6 cel/mm3), although, statistical significance was not achieved. In conclusion, a reduction of lymphocyte occurred in all subsets studied; however, furthers studies are necessary to correlate them with SLE activity.
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