DOI: 10.1097/QAI.0000000000000313

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PMID: 25314247

Issn Print: 1525-4135

Publication Date: 2014/11/01


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Successful Treatment of HIV-1 Infection Increases the Expression of a Novel, Short Transcript for IL-18 Receptor α Chain

Milena Nasi; Silvia Alboni; Marcello Pinti; Fabio Tascedda; Cristina Benatti; Stefania Benatti; Lara Gibellini; Sara De Biasi; Vanni Borghi; Nicoletta Brunello; Cristina Mussini; Andrea Cossarizza

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Author Information: Department of Surgery, Medicine, Dentistry and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy;

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Abstract

The importance of interleukin (IL)-18 in mediating immune activation during HIV infection has recently emerged. IL-18 activity is regulated by its receptor (IL-18R), formed by an α and a β chain, the IL-18–binding protein, and the newly identified shorter isoforms of both IL-18R chains. We evaluated gene expression of the IL-18/IL-18R system in peripheral blood mononuclear cells from HIV+ patients. Compared with healthy donors, IL-18 expression decreased in patients with primary infection. The IL-18Rα short transcript expression was strongly upregulated by successful highly active antiretroviral therapy. HIV progression and its treatment can influence the expression of different components of the complex IL-18/IL-18R system.

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