Issn Print: 1089-2591
Publication Date: 2006/07/01
Use of p16INK4a Cytology as a Triage Tool for the Detection of High-grade Cervical Intraepithelial Neoplasia in Women with Atypical Squamous Cells of Undetermined Significance or Low-grade Squamous Intraepithelial Cell Cytology
N. Wentzensen; C. Bergeron; F. Cas; S. Vinokurova; M. von Knebel Doeberitz
Excerpt
p16INK4a is strongly overexpressed in cervical precancerous lesions and cancer as a consequence of the deregulated expression of high-risk human papillomavirus oncogenes in the basal epithelial layers. In this study, we investigated the efficacy of p16INK4a cytology to identify high-grade cervical intraepithelial neoplasia (HGCIN) lesions among patients scored as atypical squamous cells of undetermined significance (ASCUS) or low-grade squamous intraepithelial cell (LSIL) in liquid-based cytology.
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