Issn Print: 1089-2591
Publication Date: 2006/07/01
Shift to an Immunosuppressive Microenvironment During Cervical Carcinogenesis
A. Kobayashi; T.M. Darragh; V. Weinberg; K.K. Smith-McCune
Excerpt
Immune suppression is being increasingly recognized as a pivotal aspect of carcinogenesis in many organ sites. Development of cervical cancer in the face of human papillomavirus (HPV) infection underscores the potential role of immune dysregulation in pathogenesis. Regulatory T cells (Tregs) secrete immunosuppressive cytokines such as interleukin (IL) 10. In addition, novels class of dendritic cells produce indolamine 2-3 dioxygenase (IDO), an enzyme that blocks T-cell proliferation through local depletion of tryptophan. Our previous work indicated that both cytotoxic and suppressive T cells are up-regulated in cervical intraepithelial neoplasia (CIN) 2/3 lesions compared with normal cervix. Our goal was to compare ratios of pro- and anti-inflammatory cells in the local microenvironment of HPV-induced disease.
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