Bleeding is a serious complication of patients undergoing endoscopic sphincterotomy and is the most common sphincterotomy-associated cause of death. Two patients presented bleeding after endoscopic sphincterotomy. Despite injection treatment with large amounts of epinephrine (1:10,000), the bleeding was uncontrolled. Hemostasis was achieved by placing 2 and 3 hemoclips, respectively at the bleeding site. Our cases suggest that postsphincterotomy bleeding refractory to injection treatment can be safely and effectively controlled by endoscopic hemoclipping, thereby avoiding surgery.