A Phase II Study of Troglitazone, an Activator of the PPARγ Receptor, in Patients with Chemotherapy-Resistant Metastatic Colorectal Cancer

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PURPOSETroglitazone, a potent activator of the peroxisome proliferator-activated receptor-γ, induces tumor differentiation in human lipo-sarcomas and causes regression of tumors that are derived from human colon cancer cells in nude mice. We therefore assessed the efficacy of troglitazone in the treatment of metastatic colon cancer in humans.METHODSTwenty-five patients with metastatic colorectal cancer were treated with oral troglitazone. Patients were followed up for evidence of toxicity, tumor response, and survival.RESULTSThe treatment was well tolerated: no grade 3/4 treatment-related toxicities were observed. However, no objective tumor responses were noted, and all 25 patients had progressive disease as their best response to therapy. The median progression-free survival time was only 1.6 months, and the median survival time was 3.9 months.DISCUSSIONTroglitazone is not an active agent for the treatment of metastatic colorectal cancer.

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