DOI: 10.1097/01.COT.0000350344.00532.9d

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Issn Print: 0276-2234

Publication Date: 2009/04/10


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Study: Pharmacokinetic Explanation for Ototoxicity Differences between Cisplatin & Oxaliplatin

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An animal model has shown that more cisplatin enters the inner ear than oxaliplatin does, a difference that may explain why cisplatin treatment more often causes hearing problems than oxaliplatin does, even though both are platinum compounds.
The researchers, led by Victoria Hellberg, MD, of the Karolinska Institute, measured the amount of cisplatin and oxaliplatin that reached the cochlea in guinea pigs following intravenous dosing of each drug. The total platinum concentration in the cochlea was more than five times higher with cisplatin than with oxaliplatin; and the perilymphatic drug concentration was also higher in the cisplatin-treated animals than in those exposed to oxaliplatin.
“The differences in cochlear kinetics and cellular uptake that we found in the hearing end organ are sufficient to explain the difference in ototoxicity between cisplatin and oxaliplatin,” the authors concluded.
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