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Depersonalization disorder (DPD) is a debilitating dissociative condition with no proven treatments. Although the pathophysiology of DPD is poorly understood, there are reports of increased excitability of the prefrontal cortex in patients with this condition. The temporo-parietal junction may also play a major role in the conscious experience of the spatial unity of the normal self and body. Repetitive transcranial magnetic stimulation has been shown in some case studies to effectively treat this condition. This report describes an additional such case, a 26-year-old man with a 6-month history of DPD who responded safely and significantly to repetitive transcranial magnetic stimulation to the right temporo-parietal junction.