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Gamma-Hydroxybutyric Acid (GHB) and Gamma Butyrolactone (GBL) have emerged as significant new drugs whose abuse seems to be rising. Several studies have detailed the adverse effects and dependence caused by these drugs. This article presents a brief review of GHB/GBL intoxication and withdrawal with a case presentation of a patient with GBL dependence and withdrawal. Although many patients with GHB intoxication can be discharged once the effects wear off, severe GHB withdrawal symptoms may manifest 24 to 48 hours later. These symptoms can be severe, so assessing for GHB dependence and taking precautions upon discharge are important.