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Efforts to reduce mortality from acute myocardial infarction (MI) through expediting thrombolytic and other reperfusion treatments have included the publication of clinical guidelines and standards of care for “door-to-needle” time in many countries. Across England, the National Service Framework, a national program of reform of cardiac care in the National Health Service, has resulted in, inter alia, significant reductions in treatment delay for thrombolysis-eligible patients. One component of the improvement program has been the use of service improvement methodologies, including statistical process control. We describe the early experience of 2 general hospitals in improving care of thrombolysis-eligible MI patients.