High-dose Bupivacaine Remotely Loaded Into Multivesicular Liposomes Demonstrates Slow Drug Release Without Systemic Toxic Plasma Concentrations After Subcutaneous Administration in Humans

doi:10.1097/SA.0b013e3182072bf1

DOI: 10.1097/SA.0b013e3182072bf1

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Issn Print: 0039-6206

Publication Date: 2011/02/01

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High-Dose Bupivacaine Remotely Loaded Into Multivesicular Liposomes Demonstrates Slow Drug Release Without Systemic Toxic Plasma Concentrations After Subcutaneous Administration in Humans


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High-Dose Bupivacaine Remotely Loaded Into Multivesicular Liposomes Demonstrates Slow Drug Release Without Systemic Toxic Plasma Concentrations After Subcutaneous Administration in Humans
Elyad M. Davidson,* Yechezkel Barenholz,† Rivka Cohen,† Simon Haroutiunian,*‡ Leonid Kagan,§ and Yehuda Ginosar*
(Anesth Analg, 110:1018-1023, 2010)
*Department of Anesthesiology and Critical Care Medicine, Hadassah-Hebrew University Medical Center; †Laboratory of Membrane and Liposome Research, Department of Biochemistry, Hebrew University-Hadassah Medical School; ‡Department of Pharmaceutics, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel; and §Department of Pharmaceutical Sciences, University of Buffalo, Buffalo, NY.


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