Corneal Intrastromal Gatifloxacin Crystal Deposits After Penetrating Keratoplasty

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An 85-year-old man developed faint crystallike white precipitates in the mid peripheral stroma of his left cornea 3 weeks after undergoing penetrating keratoplasty. The patient had been initially treated with 1% prednisolone acetate ophthalmic suspension and 0.3% gatifloxacin eyedrops to his left eye from the first day postoperatively. Three weeks later, the precipitates were more numerous, larger, and diffuse in distribution. Gatifloxacin was discontinued and substituted with a neomycin–polymixin B–dexamethasone ophthalmic ointment.


A detailed history, physical examination, laboratory workup, and tandem scanning confocal microscopy were performed.


Tandem scanning corneal confocal microscopy confirmed the presence of crystals in the cornea.


Gatifloxacin, a fourth-generation fluoroquinolone, can cause intrastromal macroscopic crystalline deposits through a compromised corneal epithelium, similar to what has been described for ciprofloxacin, a second-generation fluoroquinolone.

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