Peripheral nerve entrapment syndromes are difficult diagnoses to make. Symptoms are often vague and mimic other musculoskeletal pathology. Clinicians’ best diagnostic tools for entrapment neuropathies are a good history, physical examination, and anatomical knowledge. Neurodiagnostic testing and advanced imaging have some role to play in entrapment neuropathies, but these are not always necessary or helpful. Most entrapment neuropathies resolve with nonoperative treatment. This article will look at upper extremity entrapment neuropathies and review updated literature from the last decade.