What are biomarkers?

    loading  Checking for direct PDF access through Ovid

Abstract

Purpose of review

This article provides working definitions and a conceptual framework to understand the roles of biomarkers in clinical research.

Recent findings

The definitions of the terms discussed in this article – medical signs, symptoms, biomarkers, surrogate endpoints, clinical endpoints, validation – are still under discussion, as are their relationships to each other, but broad consensus has developed in the past decade and a half about the necessity of distinguishing between, in particular, surrogate and clinical endpoints.

Summary

This article outlines the major definitions of the key terms in this field and considers select cases in which misunderstandings about the terms led to flawed research conclusions.

Related Topics

    loading  Loading Related Articles