Identification of the attributes, antecedents, and outcomes of inflammation in chronic obstructive pulmonary disease (COPD) is essential. Studies examining the mediators of inflammation have investigated the physiologic, cellular, and molecular causes, but none of the findings are conclusive. This principle-based concept analysis of debilitating pulmonary inflammation focuses on identifying the mediators that initiate and exacerbate the chronic COPD process. Determining the exact mediators will help develop treatments to better target the detrimental pathogenesis of inflammation in COPD. Nurses, working together with other healthcare scientists, can improve healthcare delivery and quality of life for their patients through future research on this topic.