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Chemical burns to the eye represent a true ocular emergency, requiring immediate and proficient attention to preserve visual function. Although there have been very few reports of serious ocular burns secondary to the accidental administration of electronic cigarette liquid, this case report discusses the risk of same because of product confusion between electronic cigarette liquid and ocular preparations. This article presents a patient's case including patient history and management in the emergency department. The significance of chemical burns to the eye and its management is discussed in relation to significance to clinical practice for all nurses, nurse practitioners, and physicians working in the emergency department.