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A 48-year-old woman was unable to walk due to an extensive osteolytic supra-acetabular iliac wing metastatic lymphoma involving the arcuate line. A minimally invasive technique that combined percutaneous nailing of the iliac bone with a customized nail and cementoplasty (intraosseous injection of polymethylmethacrylate) was performed. At the 1-year follow-up, she was able to walk without crutches, and computed tomography (CT) showed a stable iliac bone fixation.Osteolytic metastasis is a common cause of bone weakening, especially in load-bearing areas. With osteolytic metastases involving the acetabulum, intraosseous injection of bone cement into the weakened acetabulum may reduce pain and prevent fracture. Nailing combined with cementoplasty may be proposed for extensive destruction of the iliac bone involving the arcuate line to relieve pain and allow for resumed walking.