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Environmental toxins from various occupational industries like oil and gas, petrochemical, agriculture, and bad eating habits cause serious health hazards. This study describes the clinical success of Modern Mayr therapy type of detoxification in a fertility practice that uses detoxification as a complementary treatment.A total of 218 infertile patients undergoing in vitro fertilization treatment from January 2014 to December 2017 at the Medical Art Center (MART) Lagos, Nigeria were referred to MART-Life Detox clinic for a supervised Modern Mayr-type of detoxification before further assisted reproductive technology treatment. Patients were placed in 2 groups. Group A consisted of 131 patients with a history of one or more failed IVF cycles at MART before commencing Mayr therapy. Group B consisted of 87 patients with no previous IVF treatment at MART. Mayr therapy using special dietary nutrition and equipment such as hypoxicator and sea oxygenator was performed. Improvement in their fertility outcomes with regards to oocyte yield, pregnancy and live birth rate were assessed in subsequent cycles following detoxification.The mean patient age was 41.53 years for group A and 40.6 years for group B. A total of 89% of all patients achieved significant weight reduction and improvement in body mass index. Uniform increase in oocyte yield was observed but this was particularly noticeable in previous poor responders in group A. Records showed positive hCG rates of 41.2% and 30%, clinical pregnancy rates of 27.5% and 21.8%, and live birth rates of 23.7% and 15%, in group A and B, respectively. There are currently 5 ongoing pregnancies in group A and 6 in group B.The data suggests that supervised modern Mayr type of detoxification may positively affect fertility indices in infertile couples who undergo assisted reproductive technology. However, there is a need for randomized controlled trials in larger populations to establish pattern of response.