Establishment of a rat model of alcoholic fatty liver and its variation following moderate-intensity exercise

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Abstract

BACKGROUND:

Aerobic exercise plays a positive role in the prevention and treatment of non-alcoholic fatty liver disease. As for alcoholic fatty liver disease, reports on it are still few.

OBJECTIVE:

To observe the moderate-intensity exercise-induced index changes of rat models with alcoholic fatty liver, so as to explore the effect of moderate-intensity exercise on alcoholic fatty liver disease.

DESIGN, TIME AND SETTING:

A randomized control animal trial was competed in the Animal Housing of Chengdu Sports University from July to September in 2007.

MATERIALS:

A total of 60 healthy male SD rats of 4-week old were divided into three groups in the experiment, with 20 ones in each group.

METHODS:

①Rats in the blank control group were injected with saline contour and they underwent no running training. ②Rats in the model control group were fed with ethanol and pinguid food by intragastric gavage and were put on the static treadmill of 0 slope, with the frequency of 30 min/d. ③Rats in the modeling exercise group were fed with ethanol and pinguid food by intragastric gavage, undergoing treadmill exercise at a speed of 25 m/min for 4 weeks, with the slope of 15% and the frequency of 30 min/d.

MAIN OUTCOME MEASURES:

The detected were contents of superoxide dismutases (SOD) and malonaldehydes (MDA) in the rat lever tissues. The histological changes were observed with histological light microscope.

RESULTS:

①The SOD activity in the blank control group was much higher than that eithther in the model control group or in the modeling exercise group (P < 0.01), and the former one reached the peak value. The SOD activity in the modeling exercise group was higher than that in the model control group (P < 0.01). ②The MDA content in the blank control group was much lower than that either in the model control group or in the modeling exercise group (P < 0.05); the MDA content in the modeling exercise group was lower than that in the model control group (P < 0.05). Furthermore, the degree of liver cell degeneration of the model control group was significantly higher than that of the blank control group (P < 0.01); the fatty degeneration of liver cells in the modeling exercise was lighter than that in the model control group (P < 0.05), but still much severer than that in the blank control group (P < 0.01).

CONCLUSION:

Appropriate training is capable of maintaining normal metabolism of free radicals in organisms, and can accordingly encourage the functional recovery of alcoholic fatty liver and limit its harm to levers.

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