Expression of receptor activator of nuclear factor kappa B ligand in root of anterior teeth development in mice

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Abstract

BACKGROUND:

Studies demonstrated that incisor continuously growing is due to lack of epithelial root sheath formation. However, researches regarding whether receptor activator of nuclear factor κB ligand (RANKL) and osteoclast has correlation with continue root development is poorly understood.

OBJECTIVE:

To observe the expression of RANKL around mouse root of incisor teeth.

DESIGN, TIME AND SETTING:

A single sample observation was performed at the Pathological Laboratory, Oral Medical Hospital, the Fourth Military Medical University from March 2007 to September 2007.

MATERIALS:

Ten brood healthy Kunming mice, 10 days old.

METHODS:

Immunohistochemistry was applied to investigate RANKL protein expression in incisor teeth.

MAIN OUTCOME MEASURES:

The expression of RANKL around mice root of incisor teeth.

RESULTS:

RANKL immunostaining was strong positive in the root of incisor teeth.

CONCLUSION:

The strong expression of RANKL in the dental follicle suggests that osteoclast was active in this region during continue root development.

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