Preparation of sustained-release ibuprofen gel*⋆

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To study the preparation, quality standard and in vitro release of sustained-release ibuprofen gel.


Sustained-release ibuprofen gel was prepared according to polylactic-co-glycolic acid (PLGA, 75/25) as base material and N-Methyl pyrrolidone (NMP) as dissolvent. In addition, a high pressure liquid chromatography (HPLC) was used to determine content, quality, and in vitro release.


The standard curve was linear in a concentration range. The average recoveries were 99.3%, 98.6%, and 100.5%, respectively. Accumulative release rate was less than 30% at the first time point (1 hour), 53%, 52%, and 55% at the middle time point (36 hours), and more than 80% at the final time point (72 hours), suggesting that sustained-release ibuprofen gel had a remarkable release effect.


The materials such as PLGA 75/25 and NMP can prepare the ideal sustained-release ibuprofen gel with a standard and reliable quality and release rate.

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